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A Hierarchical Network Controls Protein Translation during Murine Embryonic Stem Cell Self-Renewal
and Differentiation

Prabha Sampath, David K. Pritchard, Lil Pabon, Hans Reinecke, Stephen M. Schwartz, David R. Morris,
and Charles E. Murry

Stem cell differentiation involves changes in transcription, but little is known about translational control during differentiation. The authors comprehensively profiled gene expression during murine embryonic stem cell (ESC) differentiation into embryoid bodies by integrating transcriptome analysis with global assessment of ribosome loading. They show that a hierarchy of translational regulators, including mTOR, 4EBP1, and the RNA binding proteins DAZL and GRSF1, control global and selective protein synthesis during ESC differentiation. The combination of limited protein synthesis while in the pluripotent state with hierarchical translational regulation during differentiation may provide a quality control mechanism during self-renewal and fate choices of ESCs.

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Stem Cell Articles in Other Cell Press Journals

As a special service for the stem cell community, we are also providing free access to a selection of recent stem cell articles from other Cell Press journals. Please see the selections below and be sure to check this area for future updates.

 

Cell 133 (2) p250 Apr. 18, 2008
Direct Reprogramming of Terminally Differentiated Mature B Lymphocytes to Pluripotency
Jacob Hanna, Styliani Markoulaki, Patrick Schorderet, Bryce W. Carey, Caroline Beard, Marius Wernig, Menno P. Creyghton, Eveline J. Steine, John P. Cassady, Ruth Foreman, Christopher J. Lengner, Jessica A. Dausman, and Rudolf Jaenisch
[Summary] [Full Text] [PDF] [Supplemental Data]

Developmental Cell 14 (4) p494 Apr. 15, 2008
Otefin, a Nuclear Membrane Protein, Determines the Fate of Germline Stem Cells in Drosophila via Interaction with Smad Complexes
Xiaoyong Jiang, Laixin Xia, Dongsheng Chen, Yingyue Yang, Haidong Huang, Lele Yang, Qiudong Zhao, Lijun Shen, Jun Wang, and Dahua Chen
[Summary] [Full Text] [PDF] [Supplemental Data]

Developmental Cell 14 (4) p535 Apr. 15, 2008
The Tumor Suppressors Brat and Numb Regulate Transit-Amplifying Neuroblast Lineages in Drosophila
Sarah K. Bowman, Vivien Rolland, Joerg Betschinger, Kaolin A. Kinsey, Gregory Emery, and Juergen A. Knoblich
[Summary] [Full Text] [PDF] [Supplemental Data]

Neuron 58 (1) p52 Apr. 10, 2008
Oscillations in Notch Signaling Regulate Maintenance of Neural Progenitors
Hiromi Shimojo, Toshiyuki Ohtsuka, and Ryoichiro Kageyama
[Summary] [Full Text] [PDF] [Supplemental Data]

Cancer Cell 13 (4) p321 Apr. 08, 2008
Selective Inhibition of JAK2-Driven Erythroid Differentiation of Polycythemia Vera Progenitors
Ifat Geron, Annelie E. Abrahamsson, Charlene F. Barroga, Edward Kavalerchik, Jason Gotlib, John D. Hood, Jeffrey Durocher, Chi Ching Mak, Glenn Noronha, Richard M. Soll, Ayalew Tefferi, Ken Kaushansky, and Catriona H.M. Jamieson
[Summary] [Full Text] [PDF] [Supplemental Data]


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Cell Stem Cell would like to congratulate editorial board members James Thomson and Janet Rossant for their induction into the National Academy of Sciences.

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Three-Year Post-Doctoral Fellowship

We seek a postdoctoral fellow with experience in working with human ES cells to join a privately-funded laboratory in Manhattan associated with Columbia University (investigators: Drs. H. Wichterle, T.M. Jessell and C.E. Henderson). The candidate will use motor neurons derived from new ES cell lines to study disease mechanisms in ALS and SMA. The work will be carried out in collaboration with scientists at the Harvard Stem Cell Institute and the Memorial Sloan-Kettering Cancer Center. The fellowship is for 3 years. Salary in excess of $45,000, commensurate with experience Applications consisting of a full CV and covering letter with details of at least two references should be sent to: Mary Lee, Project ALS/Jenifer Estess Laboratory for Stem Cell Research, projectals.employ@gmail.com, www.projectals.org

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